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Mission Pharmacal Company is aware of the importance of protecting the privacy of visitors to our websites. Personally identifiable information, such as name, addresses, telephone numbers, and visitor comments voluntarily submitted to Mission Pharmacal Company will not be utilized for marketing purposes without obtaining visitor authorization prior to the submission of information. Mission Pharmacal Company reserves the right to utilize internally, for operations purposes, any information provided by visitors to this website.
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Mission Pharmacal Company reserves the right to revise this Website Privacy Statement, as necessary.
Medical Disclaimer
If you have a medical emergency, call 911 immediately.
The contents of this website are provided for informational purposes only. The website cannot replace your healthcare provider's medical advice, diagnosis, or treatment. Only a qualified health provider can properly address specific questions regarding your health or nutritional needs. Nothing on this website should be used to replace your healthcare provider's advice. Use of any information provided by this website is done at your own risk.
Compliance Statement
Mission Pharmacal Company has implemented Compliance Programs that include, among other provisions, a code of ethical conduct for interactions with healthcare professionals, and policies to safeguard the privacy and security of patient healthcare information.
For more information on these Compliance Programs, contact Mission Pharmacal Company's Compliance Officer at our toll-free telephone number: (800) 531-3333.
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Through your access to and use of this website, you accept, without limitation or qualification, the terms and conditions as set forth below.
If you do not wish to accept and be bound by the following terms and conditions, you may not use this website or the information contained herein.
Mission Pharmacal Company offers services and products to prevent, diagnose, and treat diseases and improve health. The prescription medications manufactured by Mission Pharmacal Company are regulated by government agencies in each of the countries in which it does business. Some of these regulations restrict the publishing of prescribing information on this website. You must speak with your qualified health care provider regarding any questions you may have regarding prescription medications and do not rely on the content of this website for such information. Nothing contained in this website is, nor shall it be construed as, medical diagnosis, treatment, or advice. Nothing contained in this website may take the place or substitute for, or augment, consultations and/or advice from physicians or other competent health care professionals or providers. See your physician or other health care provider.
Mission Pharmacal Company has developed this website as a service to consumers. However, some of the information on this website will become outdated, making it incorrect, and will only be updated periodically, if at all. As such, Mission Pharmacal Company shall not accept liability for consumer reliance on incorrect or outdated information on this website. Mission Pharmacal Company further assumes no liability or responsibility for any errors or omissions in any of the content of this website or the information contained therein.
None of the information on this website is medical advice. Consult your health care provider with questions regarding any medication or nutritional supplement. You must read the labels and inserts and follow directions on all products manufactured and/or marketed by Mission Pharmacal Company. Mission Pharmacal Company shall not be responsible for alleged damages incurred by consumers who rely on the information on this website as medical advice. By viewing this website, it is agreed that Mission Pharmacal Company shall not be liable for any direct, indirect, consequential, incidental, exemplary, or punitive damages arising out of your access to or use of this website or its contents. Additionally and separately from the above, the information provided on this website is provided "AS IS" WITHOUT ANY WARRANTIES OF ANY KIND, EITHER IMPLIED OR EXPRESSED, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT, AND MERCHANTABILITY. The exclusion of implied warranties may not be enforceable in your particular jurisdiction. Further, Mission Pharmacal Company does not assume responsibility for any damages to your computer equipment which may result from accessing and/or using this website including, without limitations, that caused by computer viruses.
This website and its contents are designed to comply with United States laws and regulations. While this website and its contents may be accessible in other jurisdictions, this website and its contents are intended for access and use in the United States only.
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YOU AGREE THAT NEITHER MISSION PHARMACAL COMPANY, ITS OFFICERS, DIRECTORS, EMPLOYEES, OR AGENTS SHALL HAVE ANY LIABILITY TO YOU UNDER ANY THEORY OF LIABILITY INCLUDING, WITHOUT LIMITATION, NEGLIGENCE OR GROSS NEGLIGENCE, OR INDEMNIFICATION, IN CONNECTION WITH YOUR USE OF THIS SITE AND/OR THE CONTENTS AND/OR INFORMATION HEREIN. YOU HEREBY RELEASE AND FOREVER WAIVE ANY AND ALL CLAIMS YOU MAY HAVE AGAINST MISSION PHARMACAL COMPANY, ITS OFFICERS, DIRECTORS, EMPLOYEES, AND/OR AGENTS BASED UPON OR RELATED TO SUCH USE.
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You agree that any dispute arising from or related to your access to or use of this website, and/or the content or information contained herein, and/or the foregoing terms and conditions, shall be governed by Texas law. You agree that exclusive venue for any dispute arising from or related to your access to or use of this website, and/or the content or information contained herein, and/or the foregoing terms or conditions, shall be exclusively in a court of competent jurisdiction in Bexar County, Texas, and you hereby agree to submit to personal jurisdiction and exclusive venue in such court of competent jurisdiction in Bexar County, Texas.
Terms and Conditions Subject to Revision
The foregoing terms and conditions are subject to revision and/or modification by Mission Pharmacal Company at anytime. Such revisions or modifications are effective immediately upon posting, publishing, or otherwise notifying you of the same. You are bound immediately by any such modifications or revisions, and consequently you should visit this page periodically to review these terms and conditions and to check for modifications or revisions.
Lithostat® is a prescription drug that prevents the excessive build-up of ammonia in your urine to control its acidity and alkalinity (pH). It may improve the effectiveness of antibiotics and help increase the cure rate in patients treated for chronic urea-splitting urinary infection.
Important Safety Information
Lithostat® should not be used in place of surgery. Surgical removal of all kidney stones, combined with antibiotics that eliminate the infection causing the stones, will provide the best chance for a cure. Lithostat® is more effective after removal of large struvite stones or stones that become lodged in the urinary tract.
Lithostat® is not for everyone. You should not take Lithostat® if your health and physical condition are a good fit for surgery and appropriate antibiotics.
Do not take Lithostat® if you are pregnant, may become pregnant, or are breastfeeding. Lithostat® contains acetohydroxamic acid (AHA), which has been linked to birth defects in laboratory animals and may cause harm to your unborn child. Some drugs can pass to infants through breast milk, and there may be serious side effects from AHA, so you should stop nursing if you are taking Lithostat®.
Do not take Lithostat® if you have poor kidney function, if your urine is infected by organisms that do not produce the enzyme urease, or if your infection can be controlled by culture-specific antimicrobial agents (antibiotics that prevent the specific type of bacteria causing your infection).
Do not take other prescription drugs or over the counter medications while you are taking Lithostat®, unless you are directed to do so by your doctor. In particular, do not take any medications that contain iron, because Lithostat® reacts with iron and both the iron and the Lithostat® may become ineffective.
AHA is eliminated primarily by the kidneys, so if you have reduced kidney function, your doctor will closely monitor you and may decrease your dosage of Lithostat® to avoid excessive build up of AHA in your system.
Liver problems have not been reported with Lithostat®. However, a compound related to AHA caused significant problems in an unrelated study, so your doctor will need to monitor your liver function.
For best results, you must take Lithostat® plus antibiotic therapy exactly as your physician prescribes it. If you don't follow your daily dosage schedule, your treatment will be less effective, and you will be likely to form new stones.
Patients that drank alcohol while taking Lithostat® have reported a flushing skin reaction (redness, warmth, and tingling), which lasted approximately 30 minutes. The reaction disappeared without treatment, however, its cause and significance are unknown, so you should not drink alcohol while taking Lithostat®.
Lithostat® may cause unknown side effects. Some reported side effects include headaches, abdominal discomfort, nausea, hair loss, shakiness, and anemia (a reduction in red blood cells). In early research, life-threatening problems (blood clot in the legs) occurred in several patients with advanced disease.
However, in more extensive, later research, these problems have not occurred. No patient has died because of taking Lithostat®. The most serious side effects seem to occur in patients with poor kidney function or those with a previous history of these conditions.
An abnormal breakdown of red blood cells (called a Coombs negative hemolytic anemia) has occurred in some patients taking AHA. The most severe forms of this condition were accompanied by gastrointestinal symptoms, such as nausea, vomiting, loss of appetite, and a general feeling of discomfort. Some patients had only laboratory findings of an anemia; however, most developed a mild reticulocytosis (an increase in immature red blood cells). The negative effects of Lithostat® disappeared after patients stopped taking the drug and began appropriate medical treatment.
Bone marrow depression (a decrease in white blood cells, red blood cells, or platelets) has occurred in laboratory animals receiving large doses of AHA; however, this has not yet been seen in humans.
There have not been acceptable long-term studies of the cancer-causing potential of Lithostat®. However, Lithostat® alters genetic material and kills tissue cells grown in lab tests. High doses of acetamide, a compound related to Lithostat®, are associated with liver cancer in laboratory rats. Therefore, Lithostat® may have the potential to cause cancer in humans.
Always report any unusual side effects to your doctor immediately. Mild symptoms usually do not call for stopping treatment. Severe symptoms may require that you stop treatment temporarily and/or change your dosage.
To report negative side effects, contact Mission Pharmacal Company at 1-800-298-1087 or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Urocit® -K (potassium citrate)
Inhibits formation of both calcium oxalate and uric acid stones
Website»
Thiola® (tiopronin)
For the prevention of cystine kidney stone formation
Website»
Lithostat® (acetohydroxamic acid)
Adjunctive therapy in patients with chronic urea-splitting urinary infection
Website»
StoneDisease.org
Information about the causes, symptoms, diagnosis, and treatment of stone disease Website»
